HT User Image

Alessandro Vannini

Selected Publications

Selected Publications

A micronutrient with major effects on cancer cell viability

Anastasia Kapara, Alessandro Vannini & Barrie Peck

2020 - Nature Metabolism


Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

Ho JSY, Angel M, Ma Y, Sloan E, Wang G, Martinez-Romero C, Alenquer M, Roudko V, Chung L, Zheng S, Chang M, Fstkchyan Y, Clohisey S, Dinan AM, Gibbs J, Gifford R, Shen R, Gu Q, Irigoyen N, Campisi L, Huang C, Zhao N, Jones JD, van Knippenberg I, Zhu Z, Moshkina N, Meyer L, Noel J, Peralta Z, Rezelj V, Kaake R, Rosenberg B, Wang B, Wei J, Paessler S, Wise HM, Johnson J, Vannini A, Amorim MJ, Baillie JK, Miraldi ER, Benner C, Brierley I, Digard P, Łuksza M, Firth AE, Krogan N, Greenbaum BD, MacLeod MK, van Bakel H, Garcìa-Sastre A, Yewdell JW, Hutchinson E, Marazzi I.

2020 - Cell


DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability

Kramm K, Schröder T, Gouge J, Vera AM, Gupta K, Heiss FB, Liedl T, Engel C, Berger I, Vannini A, Tinnefeld P, Grohmann D.

2020 - Nature Communications


Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA

Muwen Kong, Erin E. Cutts, Dongqing Pan, Fabienne Beuron, Thangavelu Kaliyappan, Chaoyou Xue, Edward P. Morris, Andrea Musacchio, Alessandro Vannini, Eric C. Greene

2020 - Molecular Cell


TFIIIC Binding to Alu Elements Controls Gene Expression via Chromatin Looping and Histone Acetylation

Roberto Ferrari, Lara Isabel de Llobet Cucalon, Chiara Di Vona, Franc¸ ois Le Dilly, Enrique Vidal, Antonios Lioutas, Javier Quilez Oliete, Laura Jochem, Erin Cutts, Giorgio Dieci, Alessandro Vannini, Martin Teichmann, Susana de la Luna and Miguel Beato

2019 - Molecular Cell


Mechanism of selective recruitment of RNA polymerases II and III to snRNA gene promoters.

Dergai O, Cousin P, Gouge J, Satia K, Praz V, Kuhlman T, Lhôte P, Vannini A, Hernandez N.

2018 - Genes & Development


Structural basis of RNA polymerase III transcription initiation.

Abascal-Palacios G, Ramsay EP, Beuron F, Morris E, Vannini A.

2018 - Nature


Structural rearrangements of the RNA polymerase III machinery during tRNA transcription initiation.

Ramsay EP, Vannini A.

2018 - Biochim Biophys Acta Gene Regul Mechanism


New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.

Gouge J, Vannini A.

2018 - Transcription


RNA polymerase I, bending the rules?

Jochem L, Ramsay EP, Vannini A.

2017 - The EMBO Journal


Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.

Gouge J, Guthertz N, Kramm K, Dergai O, Abascal-Palacios G, Satia K, Cousin P, Hernandez N, Grohmann D, Vannini A.

2017 - Nature Communications


Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.

Gouge J, Satia K, Guthertz N, Widya M, Thompson AJ, Cousin P, Dergai O, Hernandez N, Vannini A.

2015 - Cell


A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries.

Vannini A.

2013 - Biochimica et Biophysica Acta


HT User Info

Alessandro Vannini

Head of Structural Biology

Alessandro Vannini is a biochemist. He heads the Centre for Structural Biology after almost 8 years as a Principal Investigator and Deputy Head of Division at the Institute of Cancer Research in London. Alessandro is already operational in Milan at Palazzo Italia, working to develop the Centre for Structural Biology. His laboratory will focus on structural and functional analisys of large macromolecular complexes assembling around RNA Pol III loci playing a role in gene expression and structural organization of the eukaryotic genome. These mechanisms are often deregulated in human diseases, such as cancer and congenital neurodegenerative diseases. 

More info