Centro di Neurogenomica

Centro di Neurogenomica

Il Centro di Neurogenomica affronterà i meccanismi alla base dei disturbi neuropsichiatrici e neurologici, tra cui le malattie del neuro-sviluppo e della neuro-degenerazione. Integrerà ricerca di base e traslazionale attraverso diversi sistemi sperimentali e approcci computazionali (dagli organoidi cerebrali ai modelli animali alle grandi coorti epidemiologiche) per studiare la struttura, la funzione e lo sviluppo del sistema nervoso a molteplici livelli di risoluzione.

Kalebic Group Link

Kalebic Group

La ricerca del Kalebic Group si concentra sui meccanismi biologici molecolari e cellulari alla base dello sviluppo della neocorteccia umana e sulle sue implicazioni per l’evoluzione umana e i disturbi dello sviluppo neurologico.

Testa Group Link

Testa Group

Il Testa Group sfrutta il potenziale senza precedenti della riprogrammazione cellulare per studiare le basi molecolari delle malattie neuropsichiatriche e neurologiche umane (NPD), analizzando le dinamiche del loro svolgimento in modelli fisiopatologicamente rilevanti e a cavallo tra più scale di analisi: dalla risoluzione di singola cellula (single cell) alla funzione dell’organismo.

Neurogenomics Publication

Pubblicazioni

Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

Lei Xing, Nereo Kalebic, Takashi Namba, Samir Vaid, Pauline Wimberger, Wieland B. Huttner

2020 - Neuron

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Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Cristina Cheroni, Nicolò Caporale & Giuseppe Testa

2020 - Molecular Autism

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Thinking “ethical” when designing an international, cross‐disciplinary biomedical research consortium

Maria‐Elena Torres‐Padilla, Annelien L Bredenoord, Karin R Jongsma, Astrid Lunkes, Luca Marelli, Ines Pinheiro, Giuseppe Testa

2020 - The EMBO Journal

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LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski, Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Christophe Marine, John Marioni, Marc A. Marti-Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nollmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Roman-Roman, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria-Elena Torres-Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal, Thierry Voet & LifeTime Community

2020 - Nature

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The sociability spectrum: evidence from reciprocal genetic copy number variations

López-Tobón A, Trattaro S, Testa G.

2020 - Molecular Autism

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Check the commentary on PsychologyToday. 


Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD

Drakulic D, Djurovic S, Syed YA, Trattaro S, Caporale N, Falk A, Ofir R, Heine VM, Chawner SJRA, Rodriguez-Moreno A, van den Bree MBM, Testa G, Petrakis S, Harwood AJ.

2020 - Molecular Autism

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KMT2B and Neuronal Transdifferentiation: Bridging Basic Chromatin Mechanisms to Disease Actionability

G. Barbagiovanni, M. Gabriele, G. Testa​​

2020 - Neurosci Insights

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Basal Progenitor Morphology and Neocortex Evolution

Nereo Kalebic, Wieland B. Huttner

2020 - Trends in Neuroscience

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In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Nereo Kalebic, Barbara Langen, Jussi Helppi, Hiroshi Kawasaki, Wieland B. Huttner

Max Planck Institute of Molecular Cell Biology and Genetics, Human Technopole, Landesdirektion Sachsen, Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University

2020 - Journal of Visualized Experiments

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A small 7q11.23 microduplication involving GTF2I in a family with intellectual disability.

Pinelli M, Terrone G, Troglio F, Squeo GM, Cappuccio G, Imperati F, Pignataro P, Genesio R, Nitch L, Del Giudice E, Merla G, Testa G, Brunetti-Pierri N.

2020 - Clinical Genetics

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DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes.

Choufani S, Gibson WT, Turinsky AL, Chung BHY, Wang T, Garg K, Vitriolo A, Cohen ASA, Cyrus S, Goodman S, Chater-Diehl E, Brzezinski J, Brudno M, Ming LH, White SM, Lynch SA, Clericuzio C, Temple IK, Flinter F, McConnell V, Cushing T, Bird LM, Splitt M, Kerr B, Scherer SW, Machado J, Imagawa E, Okamoto N, Matsumoto N, Testa G, Iascone M, Tenconi R, Caluseriu O, Mendoza-Londono R, Chitayat D, Cytrynbaum C, Tatton-Brown K, Weksberg R.

2020 - American Journal of Human Genetics

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Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

Ayse Güven, Nereo Kalebic, Katherine R Long, Marta Florio, Samir Vaid, Holger Brandl, Denise Stenzel, Wieland B Huttner

Max Planck Institute of Molecular Cell Biology and Genetics, Germany; Human Technopole, Italy

2020 - eLife

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Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication.

Zanella M, Vitriolo A, Andirko A, Martins PT, Sturm S, O'Rourke T, Laugsch M, Malerba N, Skaros A, Trattaro S, Germain PL, Mihailovic M, Merla G, Rada-Iglesias A, Boeckx C, Testa G.

2019 - Science Advances

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