Centro di Neurogenomica

Centro di Neurogenomica

Il Centro di Neurogenomica affronterà i meccanismi alla base dei disturbi neuropsichiatrici e neurologici, tra cui le malattie del neuro-sviluppo e della neuro-degenerazione. Integrerà ricerca di base e traslazionale attraverso diversi sistemi sperimentali e approcci computazionali (dagli organoidi cerebrali ai modelli animali alle grandi coorti epidemiologiche) per studiare la struttura, la funzione e lo sviluppo del sistema nervoso a molteplici livelli di risoluzione.

Neurogenomics Publication

Pubblicazioni

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Nereo Kalebic, Barbara Langen, Jussi Helppi, Hiroshi Kawasaki, Wieland B. Huttner

Max Planck Institute of Molecular Cell Biology and Genetics, Human Technopole, Landesdirektion Sachsen, Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University

2020 - Journal of Visualized Experiments

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A small 7q11.23 microduplication involving GTF2I in a family with intellectual disability.

Pinelli M, Terrone G, Troglio F, Squeo GM, Cappuccio G, Imperati F, Pignataro P, Genesio R, Nitch L, Del Giudice E, Merla G, Testa G, Brunetti-Pierri N.

2020 - Clinical Genetics

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DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes.

Choufani S, Gibson WT, Turinsky AL, Chung BHY, Wang T, Garg K, Vitriolo A, Cohen ASA, Cyrus S, Goodman S, Chater-Diehl E, Brzezinski J, Brudno M, Ming LH, White SM, Lynch SA, Clericuzio C, Temple IK, Flinter F, McConnell V, Cushing T, Bird LM, Splitt M, Kerr B, Scherer SW, Machado J, Imagawa E, Okamoto N, Matsumoto N, Testa G, Iascone M, Tenconi R, Caluseriu O, Mendoza-Londono R, Chitayat D, Cytrynbaum C, Tatton-Brown K, Weksberg R.

2020 - American Journal of Human Genetics

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Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

Ayse Güven, Nereo Kalebic, Katherine R Long, Marta Florio, Samir Vaid, Holger Brandl, Denise Stenzel, Wieland B Huttner

Max Planck Institute of Molecular Cell Biology and Genetics, Germany; Human Technopole, Italy

2020 - eLife

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Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication.

Zanella M, Vitriolo A, Andirko A, Martins PT, Sturm S, O'Rourke T, Laugsch M, Malerba N, Skaros A, Trattaro S, Germain PL, Mihailovic M, Merla G, Rada-Iglesias A, Boeckx C, Testa G.

2019 - Science Advances

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