Neurogenomics Research Centre

Neurogenomics Research Centre

The Neurogenomics Research Centre will investigate the mechanisms of human neuropsychiatric and neurological diseases, ranging from neurodevelopmental to neurodegenerative disorders, combining basic and translational research through different experimental systems and computational approaches (from brain organoids to animal models to epidemiological cohorts) to probe the structure, function and development of the nervous system at multiple scales of resolution.

Neurogenomics Publications

Publications

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Cristina Cheroni, Nicolò Caporale & Giuseppe Testa

2020 - Molecular Autism

LINK


Thinking “ethical” when designing an international, cross‐disciplinary biomedical research consortium

Maria‐Elena Torres‐Padilla, Annelien L Bredenoord, Karin R Jongsma, Astrid Lunkes, Luca Marelli, Ines Pinheiro, Giuseppe Testa

2020 - The EMBO Journal

LINK


LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski, Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Christophe Marine, John Marioni, Marc A. Marti-Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nollmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Roman-Roman, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria-Elena Torres-Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal, Thierry Voet & LifeTime Community

2020 - Nature

LINK


The sociability spectrum: evidence from reciprocal genetic copy number variations

López-Tobón A, Trattaro S, Testa G.

2020 - Molecular Autism

LINK

Check the commentary on PsychologyToday. 


Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD

Drakulic D, Djurovic S, Syed YA, Trattaro S, Caporale N, Falk A, Ofir R, Heine VM, Chawner SJRA, Rodriguez-Moreno A, van den Bree MBM, Testa G, Petrakis S, Harwood AJ.

2020 - Molecular Autism

LINK


KMT2B and Neuronal Transdifferentiation: Bridging Basic Chromatin Mechanisms to Disease Actionability

G. Barbagiovanni, M. Gabriele, G. Testa​​

2020 - Neurosci Insights

LINK


Basal Progenitor Morphology and Neocortex Evolution

Nereo Kalebic, Wieland B. Huttner

2020 - Trends in Neuroscience

LINK


In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

Nereo Kalebic, Barbara Langen, Jussi Helppi, Hiroshi Kawasaki, Wieland B. Huttner

Max Planck Institute of Molecular Cell Biology and Genetics, Human Technopole, Landesdirektion Sachsen, Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University

2020 - Journal of Visualized Experiments

LINK


A small 7q11.23 microduplication involving GTF2I in a family with intellectual disability.

Pinelli M, Terrone G, Troglio F, Squeo GM, Cappuccio G, Imperati F, Pignataro P, Genesio R, Nitch L, Del Giudice E, Merla G, Testa G, Brunetti-Pierri N.

2020 - Clinical Genetics

LINK


DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes.

Choufani S, Gibson WT, Turinsky AL, Chung BHY, Wang T, Garg K, Vitriolo A, Cohen ASA, Cyrus S, Goodman S, Chater-Diehl E, Brzezinski J, Brudno M, Ming LH, White SM, Lynch SA, Clericuzio C, Temple IK, Flinter F, McConnell V, Cushing T, Bird LM, Splitt M, Kerr B, Scherer SW, Machado J, Imagawa E, Okamoto N, Matsumoto N, Testa G, Iascone M, Tenconi R, Caluseriu O, Mendoza-Londono R, Chitayat D, Cytrynbaum C, Tatton-Brown K, Weksberg R.

2020 - American Journal of Human Genetics

LINK


Extracellular matrix-inducing Sox9 promotes both basal progenitor proliferation and gliogenesis in developing neocortex

Ayse Güven, Nereo Kalebic, Katherine R Long, Marta Florio, Samir Vaid, Holger Brandl, Denise Stenzel, Wieland B Huttner

Max Planck Institute of Molecular Cell Biology and Genetics, Germany; Human Technopole, Italy

2020 - eLife

LINK


Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication.

Zanella M, Vitriolo A, Andirko A, Martins PT, Sturm S, O'Rourke T, Laugsch M, Malerba N, Skaros A, Trattaro S, Germain PL, Mihailovic M, Merla G, Rada-Iglesias A, Boeckx C, Testa G.

2019 - Science Advances

LINK

Check the spotlight for relevance on Trends in Genetics

Check the attention score on Altmetric